Vitamin B-12 is a cobalt-containing organic molecule that is required by the body for the synthesis of hemoglobin in red blood cells that may help the prevention of anemia. B12 exists in several forms: Cyanocobalamin is the most common form of Vitamin B12 added to foods or present in nutritional supplements. Because the major food sources of B12 are meat, eggs, and dairy products, vegetarians and vegans may require either B-12 fortified cereals or nutritional supplements to avoid health problems related to B-12 deficiency. The most prominent biochemical activity of methylcobalamin involves the enzymatic conversion of homocysteine to methionine through an enzyme-mediated transfer of the methyl group of methylcobalamin. Elevated homocysteine levels can cause a number of health problems including increased risk of heart attack and stroke, as well as a heightened risk of bone fractures. In concert with folic acid and vitamin B-6, methylcobalamin contributes to the conversion of homocysteine to cysteine, another important amino acid.

Methylcobalamin is the main form of Vitamin B-12 present in the central nervous system, helping to maintain the integrity of the myelin sheath that covers nerve fibers, and it may even help in the repair of nerve damage. Methylcobalamin can help prevent neurological problems related to vitamin B-12 deficiency, notably peripheral neuropathy and loss of coordination. These symptoms may result from nerve fiber demyelination as well as from neuronal cell death. Yet another role for methylcobalamin is in preventing or treating depression. (Two major epidemiological studies showed a relationship between vitamin B-12 deficiency and depression in elderly individuals. American Journal of Psychiatry 157:715-721, 2000 and 159:2099-2101, 2002).

Supplementation with methylcobalamin may help promote the biosynthesis of methionine, which is incorporated into proteins and is involved in other important biosynthetic reactions. Specific examples of the therapeutic uses of topical vitamin B-12 that may help prevent dermatological conditions such as atopic dermatitis (eczema) are present in the scientific literature. In a well-designed, placebo-controlled, double-blind study, topically-applied Vitamin B-12 cream significantly reduced the extent and severity of this skin disorder, possibly via an anti-inflammatory mechanism (British Journal of Dermatology 150:977-983, 2004). In another clinical trial, a topical Vitamin B-12 cream preparation was found to be useful for reducing the symptoms of psoriasis, a skin disorder related to an abnormal immune response (Dermatology 203:141-147, 2001).

In addition to Vitamin B-12 deficiency, there is a remarkably large number of medications that can promote Vitamin B-12 deficiencies. These include stomach acid-reducing drugs, oral antidiabetic drugs, extended-release potassium supplements, and exposure to the gaseous anesthetic nitrous oxide. It is believed that Vitamin B-12 deficiencies caused by exposure to medications such as these may explain the neurological and psychiatric side effects observed in individuals taking these drugs. Persons taking these medications may benefit from the use of B-12 Methylcobalamin Topical Cream.

Although Vitamin B-12 deficiency is relatively rare in young persons, it is markedly more common in older people. It is estimated that 10-30 percent of the older adult population is deficient in this vitamin. The reasons range from physiological changes, medical conditions, the increased use of specific medications that adversely affect Vitamin B-12 uptake, and decreased stomach acid secretion with age.Thus, elderly individuals may recognize health benefits from the routine use of B-12 Methylcobalamin Topical Cream.

Summary Deficiency Symptoms

• Mental Problems
• Depression
• Apathy
• Paranoia
• Memory loss
• Weakness
• Fatigue
• Diarrhea
• Pallor
• Infertility
• Nervous System Degeneration
• Lower Back Pain
• Reduced Reflexes and Sensory Perception
• Tingling In the Fingers and Toes
• Abnormal Nucleic Acid Synthesis
• Abnormal Carbohydrate Metabolism
• Changes Of Temperature In Different Parts of the Body
• Symptoms Similar to Parkinson's and/or Alzheimer's Disease
• Pernicious Anemia (Megaloblastic Anemia)

Deionized Water, Caprylic/Capric Triglyceride, Sepigel 305, Lecithin, Alcohol, Glycerin, Simugel 600, Sodium Hydroxymethylglycinate, Citric Acid, Potassium Sorbate, Lemon Verbana Oil, Methylcobalamin

Muscle cramps and fatigue, red blood cell production and neurological functioning. As directed by your healthcare professional.